NCT07331935

Efficacy of Topical Coenzyme Q10 and Curcumin for Oral Leukoplakia Treatment

Clinical and Biochemical Assessment of the Effectivness of Topical Coenzyme Q10 and Topical Curcumin in Managment of Oral Leukoplakia (A Randomized Controlled Clinical Trial)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 34 (estimated)
• Sponsor: Alexandria University · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

Oral leukoplakia (OL) is recognized as the most common potentially malignant disorder of the oral mucosa. The pathogenesis of OL is complex and multifactorial, with oxidative stress playing a central role. Topical antioxidants have gained attention as therapeutic options to help stabilize lesions and potentially prevent malignant transformation. Both CoQ10 and curcumin have demonstrated a clinical success as strong antioxidants showing their capacity to reduce the lesion size and to stabilize the disease, ultimately preventing progression into oral malignancy. Aim: This study aims to clinically and biochemically assess the effectiveness of topical Coenzyme Q10 and Curcumin in the management of homogeneous oral leukoplakia.

Conditions

• Oral Leukoplakia

Interventions

Type	Name	Description
OTHER	Coenzyme Q10 gel	Application will be performed 2-3 times daily for 4 weeks.
OTHER	Topical curcumin gel	Application will be performed 2-3 times daily for 4 weeks.

Timeline

• Start date: 2025-11-25
• Primary completion: 2026-03-30
• Completion: 2026-03-30
• First posted: 2026-01-12
• Last updated: 2026-01-12

Locations

1 site across 1 country: Egypt