| Not Yet Recruiting | Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions NCT06876038 | University of Massachusetts, Boston | Phase 2 |
| Not Yet Recruiting | Comparison of Topical Photodynamic Therapy With Topical Calcipotriol in Management of Oral Leukoplakia NCT07453472 | Dr. Shalini Gupta | Phase 3 |
| Recruiting | Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia NCT07387900 | Cairo University | Phase 2 |
| Not Yet Recruiting | Evaluation of Artificial Intelligence in Diagnosis and Risk Assessment of Oral Potentially Malignant Disorders NCT07318922 | Ain Shams University | — |
| Recruiting | Efficacy of Topical Coenzyme Q10 and Curcumin for Oral Leukoplakia Treatment NCT07331935 | Alexandria University | N/A |
| Recruiting | Fenretinide Mucoadhesive Patch: Evaluation of Oral Cancer Prevention Efficacy in Adults With Premalignant Oral NCT07149220 | Ohio State University | Phase 1 |
| Recruiting | Pioglitazone-Metformin Combination Treatment for High Risk Oral Preneoplasia NCT05727761 | University of Minnesota | Phase 2 |
| Completed | Unveiling the Protein Expression Patterns in Oral Lichen Planus and Leukoplakia Through Comparative Salivary P NCT07416318 | Kocaeli University | — |
| Recruiting | SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomograph NCT06321003 | University of Palermo | — |
| Unknown | Analyzing Handprint Patterns to Predict Oral Cancer Risks: A Comparative Study NCT06256809 | King Khalid University | — |
| Unknown | Identification of Oral Lesions Through an Autofluorescence System NCT05942794 | Federico II University | N/A |
| Active Not Recruiting | Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia NCT05237960 | University of Arizona | Phase 2 |
| Withdrawn | Intralesional 5-fluorouracil Injection for the Treatment of Oral Leukoplakia NCT05505539 | University of California, San Francisco | Phase 1 |
| Unknown | Oral Cancer Screening and Education in Hong Kong NCT04487938 | The University of Hong Kong | — |
| Unknown | Diagnostic Accuracy of Salivary Gamma-synuclein in Oral Malignant and Premalignant Lesions NCT04732741 | Cairo University | — |
| Completed | Saliva and Plasma Exosomes for Oral Leukoplakia Malignant Transformation Diagnosis and Oral Cancer Prognosis M NCT06469892 | Beijing Stomatological Hospital, Capital Medical University | — |
| Terminated | Intra and Extra Oral Inspection of Oral Mucosa NCT04079491 | Dalarna County Council, Sweden | — |
| Unknown | Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia NCT04251845 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Recruiting | Prediction of Malignant Transformation of Oral Leukoplakia Using a MAGE-A-based Immunoscore NCT03975322 | University of Erlangen-Nürnberg Medical School | — |
| Completed | Diagnostic Accuracy of Salivary DNA Integrity Index in Oral Malignant and Premalignant Lesions NCT03682562 | Cairo University | — |
| Completed | Candida Associated Cytokines in Oral Leukoplakia NCT04712929 | All India Institute of Medical Sciences | — |
| Completed | Oral Epithelial Dysplasia Informational Needs Questionnaire NCT04153266 | University College, London | — |
| Active Not Recruiting | Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion NCT02581137 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection Efficacy NCT03031899 | The Oxford Dental College, Hospital and Research Center, Bangalore, India | — |
| Terminated | Pioglitazone for Oral Premalignant Lesions NCT00951379 | National Cancer Institute (NCI) | Phase 2 |
| Unknown | Least Invasive Nonlinear Light Microscopy NCT00767442 | National Taiwan University Hospital | — |
| Terminated | Photodynamic Therapy Using Aminolevulinic Acid in Treating Patients With Oral Leukoplakia NCT00571558 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Rosiglitazone Maleate in Treating Patients With Oral Leukoplakia NCT00369174 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Photodynamic Therapy for Oral Leukoplakia and Erythroleukoplakia NCT00155337 | National Taiwan University Hospital | Phase 4 |
| Terminated | A Phase II Trial to Assess the Effects of Green Tea in Oral Leukoplakia NCT00176566 | University of Medicine and Dentistry of New Jersey | Phase 2 |
| Completed | Pioglitazone Hydrochloride in Preventing Head and Neck Cancer in Patients With Oral Leukoplakia NCT00099021 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Bowman-Birk Inhibitor Concentrate in Preventing Cancer in Patients With Oral Leukoplakia NCT00330382 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Biomarkers for Oral Cancer NCT00341497 | National Cancer Institute (NCI) | — |