NCT07331077

A Physical Activity Program Compared to Health Education for Improving Memory and Attention in Hispanic Women With Newly-Diagnosed Stage I-IIIa Breast Cancer, MAMA Trial

Movement and Memory After Breast Cancer: The MAMA Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: Female
• Age: 50 Years
• Healthy volunteers: Not accepted

Summary

This clinical trial compares a physical activity program to a health education program for improving memory and attention in Hispanic women who are 50 years of age or older and are newly-diagnosed with stage I-IIIa breast cancer. Compared to non-Hispanic White breast cancer survivors (BCS), Hispanic BCS report greater depressive symptoms, emotional distress, anxiety, fear of recurrence, pain, fatigue, and financial toxicity, in addition to more cancer-related psychosocial needs and lower quality of life and social well-being. Cancer-associated cognitive decline (CACD) is a related symptom that has gained increasing attention in clinical research. Based on disparities in other outcomes, it is likely that Hispanic BCS also experience greater CACD than non-Hispanic White BCS, but interventions targeting CACD in Hispanic BCS are non-existent and critically needed. The benefits of aerobic exercise among BCS are well documented and include improvement in health outcomes that are associated with cognitive function including fatigue, anxiety, depression, and sleep. A physical activity program that includes aerobic exercise may be more effective than simple health education for improving cognitive functions like memory and attention in Hispanic women who are 50 years of age or older and are newly-diagnosed with stage I-IIIa breast cancer.

Conditions

• Anatomic Stage I Breast Cancer AJCC v8
• Anatomic Stage II Breast Cancer AJCC v8
• Anatomic Stage IIIA Breast Cancer AJCC v8
• Cancer-related Cognitive Dysfunction

Interventions

Type	Name	Description
PROCEDURE	Accelerometry	Ancillary studies
OTHER	Aerobic Exercise	Participate in walking program
OTHER	Electronic Health Record Review	Ancillary studies
PROCEDURE	Functional Magnetic Resonance Imaging	Undergo fMRI
OTHER	Gait Assessment Test	Ancillary studies
BEHAVIORAL	Health Education	Receive health education
OTHER	Interview	Ancillary studies
OTHER	Neurocognitive Assessment	Ancillary studies
OTHER	Physical Performance Testing	Ancillary studies
OTHER	Questionnaire Administration	Ancillary studies

Timeline

• Start date: 2026-02-02
• Primary completion: 2027-11-30
• Completion: 2027-11-30
• First posted: 2026-01-09
• Last updated: 2026-01-09

Locations

1 site across 1 country: United States