Trials / Enrolling By Invitation

Enrolling By InvitationNCT07314190

Retrospective Observational Study of Blood-based Biomarkers in the Diagnosis and Monitoring of Patients With a Neurodegenerative Disease or Mental Disorder

Synapsing Retrospective Biomarker Study

Status: Enrolling By Invitation
Phase: —
Study type: Observational
Enrollment: 1,799 (estimated)

Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Academic / Other
Sex: All
Age: 18 Years
Healthy volunteers: Accepted

Summary

This is a retrospective observational study to evaluate the clinical utility of blood-based biomarkers in the diagnosis and management of patients with a neurodegenerative disease (ND) or mental disorder (MD).

Detailed description

This study will collect clinical and biomarker data from patients and controls to identify a) a blood-based diagnostic biomarker for mental disorders, and b) a blood-based biomarker that could be used as a surrogate end-point for the principal neuropsychiatric symptoms. Specific research questions are: Can blood-based biomarkers provide a faster more objective diagnosis for major depressive disorder, bipolar disorders or schizophrenia? Can the same biomarkers also aid in the differential diagnosis from neurodegenerative diseases? Do blood-based synaptic biomarkers correlate with structural and functional brain changes, cognitive performance and psychiatric symptoms in patients with major depressive disorder, bipolar disorders, schizophrenia, Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia or Parkinson's disease? Can the blood-based synaptic biomarkers predict therapeutic response in patients with major depressive disorder, bipolar disorders or schizophrenia?

Conditions

Timeline

Start date: 2026-02-19
Primary completion: 2029-06-30
Completion: 2029-12-31
First posted: 2026-01-02
Last updated: 2026-02-23

Locations

1 site across 1 country: Spain

Source: ClinicalTrials.gov record NCT07314190. Inclusion in this directory is not an endorsement.