NCT07310628

Comparison of Analgesic Efficacy of Intrathecal Levobupivacaine With and Without Oral Tizanidine in Lower Limb Surgeries: A Prospective Randomized Study

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 64 (actual)
• Sponsor: All India Institute of Medical Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Tizanidine, alpha-2 adrenergic receptor agonist, provides analgesic and hemodynamic benefits, which could enhance the efficacy of local anaesthetics. This randomized controlled trial examines the effectiveness of oral tizanidine as an adjunct to intrathecal levobupivacaine for spinal anaesthesia in lower limb surgeries

Conditions

• Tizanididne
• Levobupicaine
• Lower Limb Surgery
• Pain, Chronic

Interventions

Type	Name	Description
DRUG	Tizanidine	Group T received 3 ml of 0.5% hyperbaric levobupivacaine and 4 mg of oral tizanidine 1 hour before surgery

Timeline

• Start date: 2022-08-20
• Primary completion: 2025-07-10
• Completion: 2025-08-20
• First posted: 2025-12-30
• Last updated: 2026-01-09

Locations

1 site across 1 country: India