NCT07310407

Rutin and Vitamin C in Patients With Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD)

Evaluation of the Effect of Rutin and Vitamin C in Patients With Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD)

• Status: Not Yet Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

evaluate the combined effects of Rutin and Vitamin C versus Vitamin C alone on selected oxidative stress markers, inflammation, hepatic steatosis regression, and associated metabolic parameters in patients with MASLD

Detailed description

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a common liver disorder with risks of progression to fibrosis, cirrhosis, and hepatocellular carcinoma. Its global prevalence is high, driven by oxidative stress and impaired antioxidant defenses, while no approved pharmacological treatments currently exist. Nutritional agents such as vitamin C and rutin show promise in improving liver function and reducing oxidative damage. This study will evaluate their combined effects in addressing MASLD's multifactorial pathology.

Conditions

• NAFLD

Interventions

Type	Name	Description
DRUG	Rutin + Vitamin C	Type: Drug (Combination therapy) Details: Oral administration of two tablets containing 60 mg Rutin + 160 mg Vitamin C, taken three times daily for 12 weeks.
DRUG	Vitamin C 500mg	Type: Drug (Single agent) Oral administration of Vitamin C 500 mg, taken twice daily for 12 weeks
BEHAVIORAL	Lifestyle Intervention	Mediterranean diet focusing on fruits, vegetables, whole grains, healthy fats, plus structured exercise program for 12 weeks.

Timeline

• Start date: 2026-01-01
• Primary completion: 2027-01-01
• Completion: 2027-03-01
• First posted: 2025-12-30
• Last updated: 2025-12-30

Locations

1 site across 1 country: Egypt