NCT07298057

Effect of Arestin-Enhanced SRP on Periodontal and Glycemic Outcomes in Diabetics

Effectiveness of Scaling and Root Planing With and Without Minocycline Microspheres (Arestin) in Improving Periodontal and Glycemic Outcomes in Diabetic Patients With Periodontitis: A Randomized Controlled Trial

• Status: Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 42 (estimated)
• Sponsor: Case Western Reserve University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Periodontitis is a prevalent chronic inflammatory disease that exacerbates systemic inflammation and poses challenges for glycemic control in diabetic patients. While scaling and root planing (SRP) remains the cornerstone of periodontal therapy, adjunctive treatments such as Arestin (minocycline microspheres) have shown promise in enhancing clinical outcomes. This study aims to evaluate the impact of adding Arestin to SRP on periodontal pocket closure, glycemic control, and systemic inflammation in diabetic patients with periodontitis.

Conditions

• Periodontitis, Diabetes Mellitus Type 2

Interventions

Type	Name	Description
DRUG	local antibiotic application of topical minocycline	Scaling and Root planing + local application of Arestin ( Minocycline microsphere)
PROCEDURE	Scaling and Root Planing	Only scaling and root planing

Timeline

• Start date: 2026-02-06
• Primary completion: 2027-06-01
• Completion: 2028-06-01
• First posted: 2025-12-22
• Last updated: 2026-02-19

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study