NCT07276672

Efficacy of a Toothpaste Containing Hydrogen Peroxide as Compared to a Regular Fluoride Toothpaste Without Hydrogen Peroxide in the Immediate Removal of Tooth Stains After a Single Brushing.

Efficacy of a Toothpaste Containing Hydrogen Peroxide as Compared to a Regular Fluoride Toothpaste Without Hydrogen Peroxide in the Immediate Removal of Tooth Stains After a Single Brushing

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Colgate Palmolive · Industry
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to evaluate and compare the immediate efficacy of a hydrogen peroxide-containing toothpaste versus a regular fluoride toothpaste without hydrogen peroxide in removing extrinsic tooth stains following a single supervised brushing in healthy adult participants.

Conditions

• Whitening

Interventions

Type	Name	Description
DRUG	Optic White Adv Sparkling White (2%HP) Toothpaste	0.243% NaF toothpaste
DRUG	Colgate Great Regular Flavor Toothpaste	0.76% Na MFP

Timeline

• Start date: 2025-11-20
• Primary completion: 2025-11-24
• Completion: 2025-11-24
• First posted: 2025-12-11
• Last updated: 2025-12-11

Locations

1 site across 1 country: Dominican Republic

Regulatory

• FDA-regulated drug study