NCT07274982

The Predictive Value of Modified EASIX Score for Determining Erectile Dysfunction Severity

The Importance of Modified EASIX Score in Determining Severity of Erectile Dysfunction - A Single-Center Retrospective Case-Control Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 380 (actual)
• Sponsor: Ataturk University · Academic / Other
• Sex: Male
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This retrospective single-center case-control study evaluates whether the Modified EASIX score (LDH × CRP / Platelets), calculated from routine blood tests, predicts severity of erectile dysfunction (ED) as measured by the IIEF-5 questionnaire. Medical records from January 1, 2024 to September 30, 2025 will be reviewed. Patients will be classified by IIEF-5 (≤21 = ED; ≥22 = no ED) and Modified EASIX distributions and predictive performance (ROC/AUC) will be compared between groups. No additional interventions will be performed.

Detailed description

This retrospective observational study will include adult male patients aged 18-65 attending the urology outpatient clinic. Demographic data, comorbidities, IIEF-5 scores and routine laboratory results (LDH, CRP, platelet count and other routine biochemistry/hematology) obtained during routine follow-up will be extracted from medical records covering January 2024-September 2025. The Modified EASIX score will be computed as: LDH × CRP / Platelets. Patients will be grouped according to IIEF-5: ED group (IIEF-5 ≤21) and non-ED group (IIEF-5 ≥22). Primary analyses include group comparisons of Modified EASIX, correlation analyses with IIEF-5, logistic regression for association and ROC analysis to evaluate discriminatory performance and optimal cut-offs. Analyses will use IBM SPSS 27 and GraphPad Prism 9. No changes to patient management were made for study purposes; no additional sampling or interventions were performed.

Conditions

• Erectile Dysfunctions
• Endothelial Dysfunction
• Inflammation

Interventions

Type	Name	Description
OTHER	IIEF-5	IIEF-5: The erectile dysfunction status of patients will be analyzed with the International Index of Erectile Function-5.
OTHER	mEASIX	Endothelial function will be evaluated with mEAX.

Timeline

• Start date: 2025-05-01
• Primary completion: 2025-11-15
• Completion: 2025-11-28
• First posted: 2025-12-10
• Last updated: 2025-12-10

Locations

1 site across 1 country: Turkey (Türkiye)