NCT07271082

Efficacy and Safety of Home-based Structured Physical Exercise in Patients With Acute Ischemic Stroke

Efficacy and Safety of Home-based Structured Physical Exercise in Patients With Acute Ischemic Stroke: a Randomized Controlled, Open-label, Blinded Endpoint Trial-2 (HOPE-STROKE 2)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 208 (estimated)
• Sponsor: Capital Medical University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study is a randomized controlled, open-label, blinded endpoint trial. The investigators aim to assess the efficacy and safety of home-based structured physical exercise in participants with acute ischemic stroke.

Detailed description

The study population is participants with acute ischemic stroke within 14 days of onset. All participants are randomly assigned to the exercise intervention group or the control group in a 1:1 ratio. In the exercise intervention group, participants will undergo 90 days of home-based structured physical exercise guidance. The individualized exercise prescription will be determined based on each participant's overall condition. In the control group, participants will not receive structured physical exercise guidance but are encouraged to engage in regular physical exercise. Both groups of participants will receive standard medical management based on the latest guidelines from the American Heart Association/American Stroke Association.

Conditions

• Acute Ischemic Stroke

Interventions

Type	Name	Description
BEHAVIORAL	Exercise intervention	Subjects will undergo 90 days of home-based structured physical exercise guidance.

Timeline

• Start date: 2025-12-18
• Primary completion: 2026-09-01
• Completion: 2026-09-01
• First posted: 2025-12-08
• Last updated: 2025-12-23

Locations

6 sites across 1 country: China