NCT07269522

Arthroscopic Anterior Cruciate Ligament Reconstruction by Hamstring Graft With and Without Platelet-Rich Plasma

Functional Outcomes of Arthroscopic Anterior Cruciate Ligament Reconstruction by Hamstring Graft With and Without Platelet-Rich Plasma

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Muhammad Aamir Latif · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

No local data exists regarding the outcomes of anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma. This study aimed to compare the functional outcomes of arthroscopic anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma.

Detailed description

In animal studies, platelet-rich plasma has shown excellent results in accelerating the healing of the anterior cruciate ligament, but studies on human have shown varying clinical outcomes when investigating platelet-rich plasma for its effects on anterior cruciate ligament reconstruction. The findings of this study could provide important insights about the possible role of platelet-rich plasma in arthroscopic anterior cruciate ligament reconstruction by hamstring graft. to enhance early graft healing and reduce early complications, though its long-term effectiveness remains inconsistent. Studies suggest PRP may improve short-to-medium term outcomes like reduced pain and enhanced knee function,

Conditions

• Anterior Cruciate Ligament Injury

Interventions

Type	Name	Description
PROCEDURE	ACL reconstruction by hamstring graft with PRP	Patients underwent anterior cruciate ligament reconstruction by hamstring graft along with platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique.
PROCEDURE	ACL reconstruction by hamstring graft	Patients underwent anterior cruciate ligament reconstruction by hamstring graft without platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique.

Timeline

• Start date: 2022-01-15
• Primary completion: 2023-06-30
• Completion: 2023-06-30
• First posted: 2025-12-08
• Last updated: 2025-12-08

Locations

1 site across 1 country: Pakistan