NCT07257042

Oothpaste Containing 8% Arginine Compared to Colgate Cavity Protection Toothpaste in Reducing Dentinal Hypersensitivity

The Clinical Investigation of a Toothpaste Containing 8% Arginine Compared to Colgate Cavity Protection Toothpaste in Reducing Dentinal Hypersensitivity - an Eight-week Clinical Study in the US

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Colgate Palmolive · Industry
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to assess clinical efficacy of a toothpaste containing 8% arginine (Colgate-Palmolive Company, New York, NY, USA) to provide dental hypersensitivity relief (tactile and air blast) in comparison to Colgate Cavity Protection Toothpaste (Colgate-Palmolive Company, New York, NY, USA) over an eight-week period.

Conditions

• Hypersensitivity

Interventions

Type	Name	Description
DRUG	Toothpaste containing 8% Arginine	Brush twice daily (morning and evening) for one full minute Cover the entire length of bristles with toothpaste
DRUG	Colgate Cavity Protection Toothpaste	Brush twice daily (morning and evening) for one full minute Cover the entire length of bristles with toothpaste

Timeline

• Start date: 2025-07-14
• Primary completion: 2025-11-04
• Completion: 2025-11-04
• First posted: 2025-12-02
• Last updated: 2025-12-05

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study