NCT07228208

Role of Endothelial Dysfunction on Exercise Pressor Reflex in Type 2 Diabetes

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Medical College of Wisconsin · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Exaggerated blood pressure responses to exercise in individuals with Type 2 Diabetes significantly increase the risk of heart attack, stroke, and cardiovascular death, while also limiting exercise capacity and therapeutic benefits of physical activity. This research will determine whether impaired blood vessel function and excessive cellular damage from oxygen-containing molecules cause these dangerous blood pressure responses during exercise. The findings will establish whether targeting cellular antioxidant systems represents a new therapeutic approach to improve exercise tolerance and reduce cardiovascular risk in t Americans living with diabetes.

Conditions

• Type 2 Diabetes (T2DM)
• Endothelial Dysfunction

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	MitoQ (mitoquinol mesylate)	During each testing session, the investigators will be measuring how one treatment of an over-the-counter antioxidant supplement affects blood flow and muscle function. One day participants will orally ingest an over-the-counter antioxidant supplement called MitoQ.
DIETARY_SUPPLEMENT	Placebo	During each testing session, the investigators will be measuring how one treatment of an over-the-counter antioxidant supplement affects blood flow and muscle function. One day participants will orally ingest an over-the-counter antioxidant supplement called MitoQ, while the other they will ingest a placebo

Timeline

• Start date: 2026-09-01
• Primary completion: 2031-06-30
• Completion: 2031-12-31
• First posted: 2025-11-14
• Last updated: 2025-11-14

Locations

1 site across 1 country: United States