NCT07228065

Fixed-Dose Combinations Pragmatic Randomized Implementation Trial for Blood Pressure Control

Pharmacy-led Intervention to Increase the Adoption of Fixed-dose Single Pill Blood Pressure Lowering Medications: Hybrid Effectiveness-Implementation Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 720 (estimated)
• Sponsor: Brigham and Women's Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The proposed study is an effectiveness-implementation hybrid type II trial designed to evaluate the impact of provider- and patient-directed interventions on FDC use. The trial will test the effectiveness of theory-driven nudges tailored to address provider and patient barriers. All interventions will be pharmacist-driven, with pharmacists delivering information via nudges to providers and via nudges or more intensive interventions (i.e., CPA) to patients. Data to evaluate outcomes will be extracted from electronic health records.

Conditions

• Hypertension
• Primary Care

Interventions

Type	Name	Description
BEHAVIORAL	Provider nudge	Pharmacists will deliver targeted nudges to providers through clinical decision support integrated into the electronic health record (EHR)
BEHAVIORAL	Patient nudge	Patients will receive pharmacist-delivered nudges (e.g., text messages) 1-7 days before their visit to encourage fixed-dosed combinations
BEHAVIORAL	Pharmacist Virtual Visit	Patients will receive pharmacist counseling and prescribing delivered via virtual encounters after their visit

Timeline

• Start date: 2026-05-01
• Primary completion: 2027-03-31
• Completion: 2027-05-31
• First posted: 2025-11-13
• Last updated: 2026-03-27