NCT07223073

A Clinical Study Conducted in the Bangkok, Thailand Area, to Investigate the Clinical Efficacy of a New Toothpaste

A Randomized Single-center, Double-blind, Two-cell Parallel-group Clinical Study Conducted in the Bangkok, Thailand Area, to Investigate the Clinical Efficacy of a New Toothpaste Containing 0.454% Stannous Fluoride as Compared to a Regular Fluoride Toothpaste Containing 0.76% Sodium Monofluorophosphate in Controlling Oral Malodor 12 Hours Post-brushing Overnight After 3 Weeks of Twice a Day (Morning and Evening) Product Use.

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Colgate Palmolive · Industry
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

To investigate the clinical efficacy of a new toothpaste containing 0.454% stannous fluoride as compared to a regular fluoride toothpaste containing 0.76% sodium monofluorophosphate on oral malodor reduction via organoleptic scores 12 hours post-brushing overnight after 3 weeks of twice a day (morning and evening) product use.

Conditions

• Oral Malodor

Interventions

Type	Name	Description
DRUG	0.454% stannous fluoride	fluoride toothpaste
DRUG	0.76% sodium monofluorophosphate	regular fluoride toothpaste

Timeline

• Start date: 2017-12-21
• Primary completion: 2018-01-12
• Completion: 2018-01-12
• First posted: 2025-10-31
• Last updated: 2025-10-31

Locations

1 site across 1 country: Thailand

Regulatory

• FDA-regulated drug study