NCT07223060

Efficacy of Toothpaste Containing 0.454% Stannous Fluoride as Compared to a Regular Fluoride Toothpaste Containing 0.76% Sodium Monofluorophosphate in Controlling Supragingival Calculus Formation Over a 12-week Period.

A Randomized, Single-center, Two-cell, Double-blind and Parallel-group Design Clinical Study Conducted in the Bangkok, Thailand Area, to Investigate the Clinical Efficacy of a Test Toothpaste Containing 0.454% Stannous Fluoride as Compared to a Regular Fluoride Toothpaste Containing 0.76% Sodium Monofluorophosphate in Controlling Supragingival Calculus Formation Over a 12-week Period.

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Colgate Palmolive · Industry
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

To evaluate the comparative clinical efficacy of a test toothpaste containing 0.454% stannous fluoride as compared to a regular fluoride toothpaste containing 0.76% sodium monofluorophosphate in controlling supragingival calculus formation over a 12-week period.

Conditions

• Calculus, Dental

Interventions

Type	Name	Description
DRUG	0.454% stannous fluoride	brushed twice daily, morning and evening for 2 minutes eact time
DRUG	0.76% sodium monofluorophosphate	brushed twice daily, morning and evening for 2 minutes eact time

Timeline

• Start date: 2017-05-17
• Primary completion: 2017-10-06
• Completion: 2017-10-06
• First posted: 2025-10-31
• Last updated: 2025-12-11

Locations

1 site across 1 country: Thailand

Regulatory

• FDA-regulated drug study