NCT07199036

Clinical Application of the Effect of Respiratory Muscles Electrical Stimulation on Weaning in Patients With Difficult Weaning of the Mechanical Ventilation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 300 (actual)
• Sponsor: Capital Medical University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This trial evaluates whether transcutaneous diaphragmatic/phrenic nerve stimulation (TEDS), abdominal functional electrical stimulation (abFES), or their combination, accelerates and improves the quality of weaning from prolonged invasive mechanical ventilation (IMV), compared with standardized ICU care with sham stimulation.

Conditions

• Mechanical Ventilation

Interventions

Type	Name	Description
DEVICE	TEDS (Transcutaneous Diaphragmatic/Phrenic Nerve Stimulation)	Per session 20 min, twice daily; 5 days/week; up to 28 days or until successful weaning.
DEVICE	abFES (Functional Electrical Stimulation of Abdominal Muscles)	Per session 20 min, twice daily
DEVICE	Sham TEDS	Position/time matched; 2 Hz low-intensity sensation only; no visible contraction.
DEVICE	Sham abFES	Position/time matched; sensation only; no visible contraction.

Timeline

• Start date: 2025-09-29
• Primary completion: 2026-03-01
• Completion: 2026-03-08
• First posted: 2025-09-30
• Last updated: 2026-03-10

Locations

1 site across 1 country: China