NCT07198594

Accelerated rTMS Therapeutic Approach for Refractory Obsessive-Compulsive Disorder

A Study on the Efficacy and Safety of Accelerated Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder and Its Underlying Neurological Mechanisms

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to learn if individualized accelerated repetitive transcranial magnetic stimulation (rTMS) targeting the inferior frontal cortex combined with symptom provocation works to treat obsessive-compulsive disorders (OCD) in adults. It will also learn about the safety of rTMS over right IFC. The main questions it aims to answer are: * Does rTMS using a new individualized IFC target relieve participants' OCD symptoms? * What medical problems do participants have when taking rTMS? Participants will: * Take rTMS six times per day for 5 consecutive days * Visit the clinic once at baseline, the day and four weeks after treatment for checkups and tests

Conditions

• Obsessive Compulsive Disorder (OCD)
• Obsessive - Compulsive Disorder

Interventions

Type	Name	Description
OTHER	rTMS	individualized rTMS target the IFC with symptom provocation

Timeline

• Start date: 2025-07-03
• Primary completion: 2026-12-31
• Completion: 2027-12-31
• First posted: 2025-09-30
• Last updated: 2025-09-30

Locations

1 site across 1 country: China