Trials / Completed
CompletedNCT07184073
Cognitive Fraility and Biomarkers in Older Patients
Association Between Cognitive Fraility and Blood and CSF Biomarkers in Older Orthopedic Patients Under Regional Anesthesia
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 129 (actual)
- Sponsor
- Baskent University · Academic / Other
- Sex
- All
- Age
- 65 Years
- Healthy volunteers
- Not accepted
Summary
this study aimed to investigate the association between cognitive fraility and selected plasma and cerebrospinal fluid biomarkers related to neurodegenetaion and neuroinflammation in older adult patients undergoing elective orthopedic surgery. The main questions it aims to answer is: * Can biomarkers indicating neurodegeneration and neuroinflammation be correlated with preoperative frailty and cognitive functions? * Can these biomarkers be used as potential tools for early identification in vulnarable populations?
Detailed description
It is a cross sectional study
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | assessment Mini mental state examination | pre operatively four weeks postoperatively |
| BEHAVIORAL | assessment FRAIL scale | pre operatively four weeks postoperatively |
| OTHER | collecting cerebrospinal fluid during regional anesthesia | In the operating room regional anesthesia was administered according to the surgical plan |
Timeline
- Start date
- 2021-06-03
- Primary completion
- 2022-09-04
- Completion
- 2022-09-04
- First posted
- 2025-09-19
- Last updated
- 2025-09-19
Locations
1 site across 1 country: Turkey (Türkiye)
Source: ClinicalTrials.gov record NCT07184073. Inclusion in this directory is not an endorsement.