NCT07176299

Unilateral Laparoscopic TAP Block vs. Local Infiltration in Post-Cholecystectomy Analgesia

Efficacy of Unilateral Laparoscopic Transversus Abdominis Plane Block Compared to Local Infiltration in Postoperative Analgesia Following Laparoscopic Cholecystectomy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 160 (actual)
• Sponsor: University of Warmia and Mazury in Olsztyn · Academic / Other
• Sex: All
• Age: 20 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

This study compared different methods of pain control after laparoscopic gallbladder removal. A total of 160 patients were randomly assigned to receive either a unilateral laparoscopic TAP block, local anesthetic infiltration, a combination of both, or no regional anesthesia. Pain scores, use of pain medication, and complications were measured up to 24 hours after surgery. The TAP block group experienced less pain and fewer wound-related problems, showing that this method is safe and effective for postoperative pain relief.

Detailed description

Gallbladder stones are a common condition, and laparoscopic cholecystectomy is the standard treatment. Effective pain control after surgery is important for recovery and patient comfort. Traditionally, local anesthetic infiltration (LAI) at the surgical wound sites is used. Another method, the transversus abdominis plane (TAP) block, may provide better pain relief. This prospective, randomized clinical trial was conducted at the University Clinical Hospital in Olsztyn, Poland. A total of 160 patients undergoing elective laparoscopic cholecystectomy were randomized into four groups: TAP block, LAI, TAP+LAI, and control. All patients received the same type of anesthesia and standard pain medications. The primary goal was to compare pain intensity within 24 hours after surgery using the Numerical Rating Scale (NRS). Secondary measures included use of additional painkillers, recovery scores (Aldrete), and possible complications at the wound site. The influence of surgical drains and gallstone size on pain was also examined. The study found that the unilateral laparoscopic TAP block provided the best pain relief, fewer wound-related complications, and reduced need for additional medications compared with other methods. These results suggest that the laparoscopic TAP block is a safe and effective option for improving postoperative pain management after gallbladder surgery.

Conditions

• Cholelithiasis
• Cholecystectomy, Laparoscopic
• Pain, Postoperative
• Anesthesia, Local
• Nerve Block

Interventions

Type	Name	Description
PROCEDURE	Unilateral laparoscopic TAP block (0.25% bupivacaine)	Injection of 20 mL 0.25% bupivacaine into the transversus abdominis plane under direct laparoscopic vision.
PROCEDURE	Local anesthetic infiltration (0.25% bupivacaine)	Injection of 20 mL 0.25% bupivacaine distributed across trocar insertion sites under laparoscopic guidance.
PROCEDURE	Combined TAP block and local anesthetic infiltration (0.25% bupivacaine)	10 mL of 0.25% bupivacaine given as a TAP block and 10 mL administered as local infiltration at trocar sites.

Timeline

• Start date: 2021-09-14
• Primary completion: 2023-06-30
• Completion: 2023-06-30
• First posted: 2025-09-16
• Last updated: 2025-09-22

Locations

1 site across 1 country: Poland