NCT07165483

Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation?

Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation? A Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (estimated)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study aims to evaluate the effect of increasing preoperative timing of single dexmedetomidine on the stress response of laryngoscopy and intubation.

Detailed description

Maintaining hemodynamic stability during surgery is one of the most important tasks because good anesthesia increases the success rate of surgery and improves postoperative prognosis. Dexmedetomidine, a potent α2-adrenoreceptor agonist, produces not only a sedative-hypnotic effect, but in situations involving cardiac risk, it also produces analgesic effects and an autonomic blocking effect, by acting on a single type of receptor.

Conditions

• Time
• Dexmedetomidine
• Stress Response
• Laryngoscopy
• Intubation

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	Patients will receive 0.5µg/kg dexmedetomidine (over 10 min) 20 min before induction of anesthesia then saline (over 10 min) 10 min before induction of anesthesia.
DRUG	Dexmedetomidine	Patients will receive saline (over 10 min) 20 min before induction of anesthesia then 0.5µg/kg dexmedetomidine (over 10 min) 10 min before induction of anesthesia.
DRUG	Saline	Patients will receive saline before induction of anesthesia as a control group.

Timeline

• Start date: 2025-09-11
• Primary completion: 2026-03-01
• Completion: 2026-03-01
• First posted: 2025-09-10
• Last updated: 2025-09-12

Locations

1 site across 1 country: Egypt