Trials / Recruiting

RecruitingNCT07163689

TIPS for Complicated Portal Hypertension Related to Porto-Sinusoidal Vascular Disease

TIPS for the Management of Complicated Portal Hypertension Related to Porto-Sinusoidal Vascular Disease

Status: Recruiting
Phase: —
Study type: Observational
Enrollment: 360 (estimated)

Sponsor: Centre Hospitalier Universitaire, Amiens · Academic / Other
Sex: All
Age: 18 Years
Healthy volunteers: Not accepted

Summary

Porto-sinusoidal Vascular Disease (PSVD) is characterized by a portal hypertension (PH) without cirrhosis. This can induce PH complications, like digestive hemorrhage from esophageal or gastric varices, ascites, or even portal thrombosis. Due to the rarity of MVPS, the treatment of complications of portal hypertension is modeled on the methods used in cirrhotic portal hypertension with non-cardio-selective beta blockers, endoscopic ligations or diuretics in first line therapy, as proposed by the Baveno VII recommendations. In complicated or refractory forms of PH in PSVD, the place of TIPS is also discussed, as in the field of cirrhosis. However, the experience of TIPS in PSVD is limited, reported in case reports and small specifically dedicated series. No predictive factors for survival or recurrence and tolerance were well known. A larger study with control group is needed in order to better know the right time and the right indication for the use of TIPS in complicated PH PSVD-related. The study will be retrospective, multicentric involving tertiary university French centers, expert in the management of TIPS. Patients white TIPS-PSVD will be compared with historical patients with TIPS-cirrhose, matched on age, sexe, indication of TIPS. The study will not comprise new intervention, only observational in a real life condition

Conditions

Timeline

Start date: 2025-05-16
Primary completion: 2025-12-01
Completion: 2025-12-01
First posted: 2025-09-09
Last updated: 2025-11-19

Locations

1 site across 1 country: France

Source: ClinicalTrials.gov record NCT07163689. Inclusion in this directory is not an endorsement.