Trials / Not Yet Recruiting

Not Yet RecruitingNCT07157670

Cardiovascular Complications in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.

Status: Not Yet Recruiting
Phase: —
Study type: Observational
Enrollment: 400 (estimated)

Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
Sex: All
Age: 15 Years
Healthy volunteers: Not accepted

Summary

Allogeneic hematopoietic stem cell transplantation (HSCT) represents a major therapeutic strategy for malignant hematologic diseases, with the number of procedures steadily increasing in France each year. Conditioning and maintenance regimens carry a risk of both short- and long-term cardiotoxicity, leading to serious cardiovascular events including acute coronary syndrome (ACS), cardiac dysfunction, arrhythmias, pulmonary hypertension, and pericardial effusion. The pathophysiology of cardiotoxicity in HSCT patients remains poorly understood. It is therefore crucial to investigate underlying mechanisms and identify predictive factors of cardiotoxicity in order to provide appropriate cardiological follow-up and management. Current European Society of Cardiology guidelines recommend routine monitoring of HSCT patients with echocardiography and cardiac biomarkers (NT-proBNP, troponin), although these recommendations are based on small-scale studies. The cardiodepressor factor DPP3 has shown promising results in cardio-oncology, with a causal role in anthracycline-induced cardiac dysfunction. Its role in HSCT-related cardiotoxicity requires further evaluation. This multicenter study of HSCT recipients will be a valuable resource, enabling a better understanding of the pathophysiology of cardiotoxicity and prognosis. It will highlight imaging (echocardiography, calcium score, supra-aortic Doppler), electrocardiographic, and biological markers (including DPP3) associated with prognosis.

Conditions

Timeline

Start date: 2025-09-15
Primary completion: 2027-12-25
Completion: 2028-09-15
First posted: 2025-09-05
Last updated: 2025-09-05

Source: ClinicalTrials.gov record NCT07157670. Inclusion in this directory is not an endorsement.