NCT07152795

Probiotics for Alleviating Chronic Constipation in Adults

Weizmannia Coagulans BC99 Improved Intestinal Motility and Chronic Constipation Through Regulating Gut Microbiota: A Randomized, Double-blind, Placebo-controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Wecare Probiotics Co., Ltd. · Industry
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

To investigate the clinical effects of probiotics in relieving intestinal motility and chronic constipation through regulating gut microbiota.

Conditions

• Constipation

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Probiotic	During the intervention, participants can consume BC99 daily and any adverse reactions were noted. Stool and serum samples were collected for analysis of 16S rRNA and serum inflammatory markers. Changes in intestinal flora and inflammatory factors before and after supplementation were assessed.
DIETARY_SUPPLEMENT	Placebo	During the intervention, participants can consume maltodextrin daily and any adverse reactions were noted. Stool and serum samples were collected for analysis of 16S rRNA and serum inflammatory markers. Changes in intestinal flora and inflammatory factors before and after supplementation were assessed.

Timeline

• Start date: 2024-04-30
• Primary completion: 2024-06-25
• Completion: 2024-10-10
• First posted: 2025-09-03
• Last updated: 2025-09-03

Locations

1 site across 1 country: China