NCT07147972

Comparative Study of Nutraceuticals vs. Conventional Prophylactic Therapy in the Management of Migraine

• Status: Not Yet Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Fayoum University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Migraine is a common disabling neurological condition that significantly affects quality of life. While traditional prophylactic treatments (e.g., beta-blockers, antiepileptics) are effective, they may be associated with side effects leading to poor adherence. Recent evidence suggests that nutraceuticals like magnesium, riboflavin, and coenzyme Q10 may provide a safer alternative. This study aims to compare the efficacy and tolerability of these two approaches.

Detailed description

Primary Objective: \- To compare the reduction in the frequency of migraine attacks between patients receiving conventional prophylactic therapy and those receiving a nutraceutical combination. Secondary Objectives: * To evaluate changes in migraine intensity (VAS score), duration, and MIDAS score. * To assess the side effect profile and patient satisfaction with both interventions.

Conditions

• Migraine
• Nutraceuticals

Interventions

Type	Name	Description
DRUG	Propranolol 80 mg	Propranolol 40-80 mg/day
DRUG	Magnesium 400Mg	Magnesium 400 mg daily

Timeline

• Start date: 2025-08-20
• Primary completion: 2026-02-01
• Completion: 2026-02-01
• First posted: 2025-08-29
• Last updated: 2025-08-29