NCT07127835

Provocation After Nurse-Directed Assessment (PANDA) Study

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 440 (estimated)
• Sponsor: The University of Hong Kong · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study aims to evaluate the effectiveness and safety of a collaborative nurse-allergist approach in penicillin allergy delabeling services. It also seeks to assess the impact on patients' quality of life and compare resource utilization and cost-effectiveness between the nurse-allergist collaborative approach and the traditional allergist-led approach.

Detailed description

This study hypothesizes that by involving both nurses and allergists in the delabeling process and categorizing patients based on risk levels, it will achieve comparable success rates, safety, and improvements in patients' quality of life. This approach is expected to offer superior advantages in terms of time efficiency, resource utilization, and cost-effectiveness compared to traditional allergist-led services.

Conditions

• Drug Allergy
• Penicillin Allergy

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Nurse-led penicillin allergy delabelling service	Patients in this group undergo risk assessment and categorization by nurses to identify low-risk individuals for delabeling. For these patients, nurses will collaborate with allergists in the delabeling process.
DIAGNOSTIC_TEST	Allergist-led penicillin allergy delabelling service	Patients assigned to this group will undergo risk assessment and delabeling led by allergists for both low-risk and high-risk cases.

Timeline

• Start date: 2025-09-01
• Primary completion: 2027-08-31
• Completion: 2029-08-31
• First posted: 2025-08-17
• Last updated: 2025-10-01

Locations

4 sites across 1 country: Hong Kong