NCT07122232

Comparative Study of Thrombocytopenia in Plasmodium Vivax and Falciparum Malaria

Comparative Analysis of Thrombocytopenia in Plasmodium Vivax and Plasmodium Falciparum Malaria: A Prospective Cross-Sectional Study From a Tertiary Care Hospital in Peshawar, Pakistan

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 177 (actual)
• Sponsor: Rafiullah Hotak · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

This study aimed to compare platelet count patterns in patients infected with either Plasmodium vivax or Plasmodium falciparum, the two most common malaria species in Pakistan. Thrombocytopenia (low platelet count) is a common complication of malaria and can help in identifying disease severity. We conducted this research at a tertiary care hospital in Peshawar, Pakistan, from April to September 2023. A total of 171 adult patients with confirmed malaria infections were enrolled. We measured their platelet counts at admission, day 3, and day 7, and analyzed the severity and progression of thrombocytopenia. The study found that while P. vivax was more common, P. falciparum was more likely to cause severe thrombocytopenia. Understanding these differences helps healthcare providers identify high-risk patients earlier and manage malaria more effectively. The study was approved by the institutional review board of Lady Reading Hospital, Peshawar.

Conditions

• Malaria
• Plasmodium Vivax Infection
• Plasmodium Falciparum Infection
• Thrombocytopenia

Timeline

• Start date: 2023-04-01
• Primary completion: 2023-09-30
• Completion: 2023-09-30
• First posted: 2025-08-14
• Last updated: 2025-08-14

Locations

1 site across 1 country: Pakistan