NCT07118618

Probenecid Administration for Alcohol Craving and Consumption

Probenecid, Pannexin 1 Channels for Alcohol Use Disorder

• Status: Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Brown University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study proposes a 16-week, between-subject, double-blind, randomized controlled trial (RCT) with probenecid (2g /day) compared to placebo in individuals with AUD to test if reduces craving and alcohol consumption.

Detailed description

There are three aims in this study that test the hypothesis that probenecid compared to placebo, decreases: * Aim 1 (laboratory phase): acute alcohol craving. * Aim 2 (naturalistic phase): alcohol craving. * Aim 3 (naturalistic phase): alcohol consumption

Conditions

• Alcohol Use Disorder (AUD)
• Alcohol Consumption
• Craving

Interventions

Type	Name	Description
DRUG	Probenecid Oral Tablet	2gr daily
DRUG	Placebo Oral Tablet	Inactive compound

Timeline

• Start date: 2026-03-14
• Primary completion: 2030-12-31
• Completion: 2030-12-31
• First posted: 2025-08-12
• Last updated: 2026-03-17

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study