NCT07103564

The Effect of Local Melatonin Application Around Immediately Placed Implants in the Maxillary Premolar

The Evaluation of the Effect of Local Melatonin Application Around Immediately Placed Implants in the Maxillary Premolars (Randomized Controlled Clinical Trial)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Hams Hamed Abdelrahman · Academic / Other
• Sex: All
• Age: 25 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Background: Immediate implants provide ideal three-dimensional positioning compared to conventional implants. There may be a gap between the surface of the implant and the bone walls of the socket when it is inserted into a recently extracted alveolus. To compensate for this, various grafting materials are used. Recently, melatonin has gained significant attention because of its inhibitory action on bone resorption through upregulating the expression of osteoprotegerin, which acts as a decoy receptor for RANKL and inhibits its binding to osteoclast precursors thereby inhibiting osteoclast formation and activity. So, we will conduct this study to evaluate the effects of local melatonin application around immediately placed implants. Aim of the study: To evaluate the effectiveness of adding local melatonin around immediately placed implants in maxillary premolars.

Conditions

• Dental Implants
• Osteoprotegerin
• Melatonin

Interventions

Type	Name	Description
OTHER	Immediately placed implant in maxillary premolars with local melatonin application	Patients will receive immediately placed implants with local melatonin powder (3mg) application.
OTHER	Immediately placed implant in maxillary premolars without local melatonin application	Patients will receive immediately placed implants without local melatonin application.

Timeline

• Start date: 2024-07-01
• Primary completion: 2025-07-15
• Completion: 2025-07-15
• First posted: 2025-08-05
• Last updated: 2025-08-05

Locations

1 site across 1 country: Egypt