NCT07102134

The Modified Clipped-LIFT Procedure for High Transsphincteric or Suprasphincteric Fistula

The Modified Clipped Ligation of Intersphincteric Fistula Tract (Clipped-LIFT) for High Transsphincteric or Suprasphincteric Fistula: a Proof-of-concept Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 96 (actual)
• Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

A retrospective analysis was performed on 96 patients who underwent modified LIFT procedures to treat transsphincteric or suprasphincteric fistulas. Two distinct methods were utilized to ligate the internal sphincter side of the intersphincteric tract: one group received conventional ligation with absorbable sutures (Suturing-LIFT, n=74), while the other group was treated with absorbable clips commonly used for vascular or biliary duct occlusion (Clipped-LIFT, n=22). The primary outcome was the one-stage healing rate, which was compared between the two groups, and the safety profile of the clipped-LIFT approach was analyzed. Both univariate and multivariate analyses were conducted to identify potential prognostic factors associated with therapeutic outcomes.

Conditions

• Anal Fistula Surgery
• Anal Fistula

Interventions

Type	Name	Description
PROCEDURE	Suturing-LIFT procedure	This group received conventional ligation with absorbable sutures
PROCEDURE	Clipped-LIFT procedure	This group was treated with absorbable clips commonly used for vascular or biliary duct occlusion

Timeline

• Start date: 2020-03-01
• Primary completion: 2020-03-13
• Completion: 2025-05-15
• First posted: 2025-08-03
• Last updated: 2025-08-03

Locations

1 site across 1 country: China