NCT07094061

Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 294 (estimated)
• Sponsor: University of Michigan · Academic / Other
• Sex: All
• Age: 18 Years – 20 Years
• Healthy volunteers: Accepted

Summary

This study seeks to understand individual differences in personality, brain function, and behavior. Study hypothesis: \- A stronger sign-tracking bias will be associated with a bottom-up processing style characterized by less adaptive attentional- and impulse-control as well as hyperactive reward processing, whereas a stronger goal-tracking bias will be associated with a top-down processing style characterized by strong attentional- and impulse-control as well as normative reward processing.

Conditions

• Substance Use
• Healthy

Interventions

Type	Name	Description
DEVICE	fMRI	Participants will have an MRI to scan participants brains and will wear skin conductance electrodes on the hand and fill out questionnaires. Scanning will take approximately 90 minutes. While lying in the scanner, participants will be asked to perform some tasks. The tasks will be presented to participants visually on a screen in the scanner and eye movements will also be tracked during some of these tasks. Participants will respond to stimuli with button presses that are recorded by computer.
BEHAVIORAL	Questionnaires and surveys	Participants will have multiple visits during this study and fill out various surveys at these visits.
BEHAVIORAL	Behavioral tasks and eye tracking	Participants will perform behavioral tasks while having eye-tracking hardware monitor participants eye movements. A video camera will be used to record eye movements during the behavioral tasks.

Timeline

• Start date: 2025-10-03
• Primary completion: 2027-10-01
• Completion: 2027-10-01
• First posted: 2025-07-30
• Last updated: 2025-10-14

Locations

2 sites across 1 country: United States