NCT07093723

Protein S100B Versus Neutrophils/Lymphocytes Ratio in Early Prediction of Brain Injury

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: 28 Weeks – 36 Weeks
• Healthy volunteers: Not accepted

Summary

The study aimed to evaluate the role of Protein S100B versus the neutrophil-to-lymphocyte ratio (NLR) as an early predictor biomarker and the value of amplitude-integrated electroencephalography (aEEG) as an early predictor and prognostic method for neonatal brain injury susceptibility and severity.

Detailed description

The most prevalent types of newborn brain injury (NBI) are intraventricular haemorrhage (IVH), periventricular leukomalacia (PVL), and hypoxic-ischemic encephalopathy (HIE), which can affect neonates born at any gestational age (GA). Amplitude-integrated EEG (aEEG) is another early predictor and prognostic technique for Neonatal Brain Injury. Electrophysiological brain activity, as measured by aEEG, is a well-established method for giving information on the functional and metabolic status of the brain and the incidence of epileptic seizure episodes. S100B belongs to the S100 family. Because it is soluble in a 100% saturated solution of ammonium sulfate, it was designated "S100." S100 protein is a calcium-binding cytosolic protein with a molecular weight of 21 kDa comprised of 2 monomers, which are found in a variety of cells and are primarily concentrated in the glial cells of the CNS. Due to its molecular weight, peripheral blood will detect only S100B. The neutrophil-to-lymphocyte ratio (NLR) reflects changes in neutrophil and lymphocyte levels, which is an indication of inflammation.

Conditions

• S100B
• Neutrophils/Lymphocytes Ratio
• Prediction
• Brain Injury

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	S100B Protein	Serum level of S100B Protein was measured on the first and third days of seizure activity by ELISA.
DIAGNOSTIC_TEST	Neutrophils to Lymphocytes ratio	Neutrophils to Lymphocytes ratio was measured on the first and third day of seizure activity obtained by complete blood count.

Timeline

• Start date: 2023-09-01
• Primary completion: 2024-03-01
• Completion: 2024-03-01
• First posted: 2025-07-30
• Last updated: 2025-07-30

Locations

1 site across 1 country: Egypt