NCT07082101

Temporal Interference for Temporal Lobe Epilepsy Under SEEG

Evaluating Biomarkers of Temporal Interference for Temporal Lobe Epilepsy Under SEEG

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: Xijing Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates the effect of temporal interference (TI) stimulation on biomarkers in patients with temporal lobe epilepsy (TLE) under stereo-electroencephalography (SEEG), and provides theoretical basis for non-invasive TI treatment of temporal lobe epilepsy.

Detailed description

10 patients aged 18-65 years with TLE assessed by semiology, video electroencephalogram and imaging in Epilepsy Center of Xijing Hospital (Xi'an, China) will be recruited. Clinical baseline data such as general information and history of seizures will be collected. The SEEG electrodes were implanted in the Department of neurosurgery of Xijing Hospital and after 24 hours TI will be performed with continuous SEEG monitoring. Finally, the biomarker changes of EEG signals before and after TI treatment were statistically analyzed.

Conditions

• Epilepsy

Interventions

Type	Name	Description
OTHER	temporal interference	In this intervertion, patients with SEEG operation will take temporal interference (TI) stimulation and the deep brain EEG will be monitorated through the entire experiment.

Timeline

• Start date: 2025-08-15
• Primary completion: 2026-07-01
• Completion: 2026-08-01
• First posted: 2025-07-24
• Last updated: 2025-07-24

Locations

1 site across 1 country: China