NCT07062939

Comparative Effects of Mechanical and Manual Airway Clearance Techniques in Cystic Fibrosis

Comparative Effects of Manual Versus Mechanical Airway Clearance Techniques in Cystic Fibrosis

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (estimated)
• Sponsor: Riphah International University · Academic / Other
• Sex: All
• Age: 16 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

This study will help to establish evidence-based physiotherapy on postural drainage and ACBT against flutter with ACBT is better to improve sleep quality, adherence, dyspnea in patients with cystic fibrosis and which method can improve respiratory function, reduce the risk of complications after illness and additionally advancements in respiratory therapy can lead to improve sleep quality, individual preference and adherence and dyspnea.

Detailed description

Cystic fibrosis (CF) is a genetic disorder that leads to the accumulation of thick mucus in the lungs and other organs, resulting in recurrent infections and progressive lung damage. This condition is due to mutations in the cystic fibrosis transmembrane conductance regulator CFTR gene, which governs the transport of chloride and other ions across cell membranes. CF affects a significant number of people worldwide, with certain genetic mutations leading to more severe manifestations of the disease. The management of CF is centered on clearing the airways of mucus to prevent infections and slow the progression of lung damage. Various studies have yielded inconsistent results regarding the comparative effectiveness of manual versus mechanical airway clearance techniques in improving pulmonary function tests (PFTs) in CF patients. Despite the existing literature on postural drainage with ACBT in patient with cystic fibrosis, there is a significant research gap regarding the flutter and ACBT on the bases of outcomes in cystic fibrosis. Most studies have not adequately addressed the distinct needs and responses of flutter with ACBT on the basis of outcomes, leaving a void in understanding how these two intervention effect on sleep, adherence and dyspnea in the context of patients with cystic fibrosis. Closing this gap is essential for developing evidence-based and pulmonary rehabilitation techniques for this specific patient group.

Conditions

• Cystic Fibrosis

Interventions

Type	Name	Description
OTHER	postural drainage with ACBT	postural drainage and ACBT for 2 times a day for 30 min for 4 weeks.
OTHER	flutter with ACBT	flutter with active cycle breathing technique for 30 min. for 4 week and 2 times a day.

Timeline

• Start date: 2025-07-06
• Primary completion: 2025-11-30
• Completion: 2025-12-30
• First posted: 2025-07-14
• Last updated: 2025-07-14

Locations

1 site across 1 country: Pakistan