NCT07062757

Lymphatic Drainage Massage and Melatonin in Post-Orthognathic Surgery Pain and Edema

The Effect of Lymphatic Drainage Massage and Melatonin on Pain and Edema After Orthognathic Surgery.

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Bezmialem Vakif University · Academic / Other
• Sex: All
• Age: 16 Years – 55 Years
• Healthy volunteers: Accepted

Summary

Lymphatic drainage massage is one of the most essential techniques for reducing edema. It is a very gentle, monotonous, slow, rhythmic massage applied to the skin's surface. This technique accelerates the flow of lymphatic fluid, minimizing swelling and providing relief. Frequently used after orthognathic surgery, lymphatic drainage massage helps reduce edema, enhancing patients' postoperative comfort.

Detailed description

Melatonin, a hormone produced by the pineal gland, is a neurochemical substance that functions in harmony with the body's natural rhythm. In addition to its presence in the brain, melatonin can also be found in the retina, bone marrow, intestines, skin, and various blood cells. Conditions such as insomnia or jet lag may benefit from melatonin supplements. Beyond its role in improving sleep quality, melatonin also contributes to regulating the immune system, body temperature, blood pressure, and cortisol hormone levels. Another important function of melatonin is its powerful free radical-scavenging ability. It can neutralize both reactive oxygen species and reactive nitrogen species. Due to its strong antioxidant properties, several studies have investigated its effects on pain and edema. Research has shown that preoperative and postoperative melatonin administration can reduce postoperative pain and accelerate sensory recovery through its antioxidant effects.

Conditions

• Dentofacial Deformities
• Edema
• Pain

Interventions

Type	Name	Description
OTHER	no intervention	this group patients receive any medication for edema control.
OTHER	lymphatic drainage massage	A total of 10 sessions of lymphatic drainage massage will be applied to this group of patients, starting from the 2nd postoperative day, with 2 sessions per week.
DIETARY_SUPPLEMENT	oral melatonin tablet	In this group of patients, the first dose of 10 mg oral melatonin tablet will be given one day prior to the operation, and the patients will continue taking the tablet daily for a total of 21 days.
COMBINATION_PRODUCT	both melatonin and lymphatic drainage	In this group of patients, a total of 10 sessions of lymphatic drainage massage will be applied starting from the 2nd postoperative day, with 2 sessions per week, while the first dose of 10 mg oral melatonin tablet will be administered one day prior to the operation, and the patients will continue taking the tablet daily for 21 days.

Timeline

• Start date: 2025-03-30
• Primary completion: 2027-03-30
• Completion: 2027-05-30
• First posted: 2025-07-14
• Last updated: 2025-07-14

Locations

1 site across 1 country: Turkey (Türkiye)