NCT07059143

6 Weeks Right-Amygdala TIS for Depression

A Multicenter Randomized Double-Blind Controlled Trial of Six-Week Transcranial Temporal Interference Stimulation（TIS） Targeting the Right Amygdala for Rapid Alleviation of Depressive Symptoms.

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Ruijin Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The current investigation employs a directed neuromodulation technique, specifically targeting the right amygdala, to ascertain its therapeutic efficacy in managing depressive episodes. The intervention's safety and efficacy will be evaluated using an assessment incorporating depressive symptomatology, cognitive abilities, and daily functions.

Conditions

• Major Depressive Disorder (MDD)

Interventions

Type	Name	Description
DEVICE	Nervio-X	An 8-channel TIS device developed by NEURODOME Corporation.

Timeline

• Start date: 2025-05-27
• Primary completion: 2025-12-31
• Completion: 2026-12-31
• First posted: 2025-07-10
• Last updated: 2025-07-10

Locations

3 sites across 1 country: China