NCT07056881

Monotherapy vs Combination Therapy for Bone Infections Caused by Pseudomonas Aeruginosa

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: Centre Hospitalier de Saint-Denis · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

This study looks at how well one antibiotic (monotherapy) works compared to two antibiotics (combination therapy) in treating bone infections caused by Pseudomonas aeruginosa. It includes 300 adult patients who had this type of infection confirmed by lab tests and medical imaging. The goal is to find out if using just one antibiotic is as effective as using two, while also looking at side effects, the need for more surgery, antibiotic resistance, and overall antibiotic use.

Conditions

• Osteomyelitis
• Pseudomonas Infections
• Pseudomonas Aeruginosa
• Bacterial Infections

Timeline

• Start date: 2025-04-11
• Primary completion: 2026-04-15
• Completion: 2026-04-15
• First posted: 2025-07-09
• Last updated: 2025-07-09

Locations

1 site across 1 country: France