NCT07049003

Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor

• Status: Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: The Cleveland Clinic · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Not accepted

Summary

This objective of this study is to document the safety and feasibility of electrical stimulation of the deep cerebellar nuclei for refractory tremor using the Medtronic Percept RC Deep Brain Stimulation System. The population will consist of patients that have either failed a prior intervention (Vim DBS or HIFU thalamotomy) or determined to not be suitable candidates for Vim DBS or HIFU thalamotomy because they have a cerebellar outflow or MS-related tremor. Those patients with a previous intervention, must have a prior diagnosis of ET, cerebellar outflow tremor, or MS-related tremor. Subjects without a previous intervention must have a diagnosis of cerebellar outflow tremor or MS-related tremor.

Conditions

• Tremor
• Essential Tremor

Interventions

Type	Name	Description
DEVICE	Deep Brain Stimulation	Deep Brain Stimulation of the Deep Cerebellar Nuclei

Timeline

• Start date: 2025-05-19
• Primary completion: 2028-12-31
• Completion: 2028-12-31
• First posted: 2025-07-03
• Last updated: 2025-07-03

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study