NCT07044830

Obstructive Sleep Apnea Treatment From Acute to Chronic Phase of Stroke

Obstructive Sleep Apnea Treatment From Acute to Chronic Phase of Stroke - A Randomized Clinical Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 425 (estimated)
• Sponsor: Hospital das Clínicas de Ribeirão Preto · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The study aims to evaluate whether early treatment of obstructive sleep apnea with continuous positive airway pressure in ischemic stroke patients has a favorable effect on functional recovery.

Detailed description

Obstructive sleep apnea (OSA) is present in more than 70% of acute stroke patients, and has been related to poor short-and long-term outcomes. The treatment of choice for OSA is continuous positive airway pressure (CPAP). The objective of this prospective, multicenter, randomized study is to evaluate the impact of CPAP treatment on clinical outcomes in post-stroke patients. Respiratory polygraphy will be performed in all eligible participants, and those with severe OSA will be randomized to receive either CPAP therapy or conservative management. CPAP use will initiated within the first 48-72 hours of hospital admission and continued through 2 years follow-up.

Conditions

• Ischemic Stroke
• Obstructive Sleep Apnea

Interventions

Type	Name	Description
DEVICE	CPAP	Automatically-adjusting continuous positive airway pressure (CPAP)

Timeline

• Start date: 2024-02-28
• Primary completion: 2029-02-28
• Completion: 2031-02-28
• First posted: 2025-07-01
• Last updated: 2025-07-01

Locations

1 site across 1 country: Brazil