Trials / Not Yet Recruiting
Not Yet RecruitingNCT07036991
Clinical Trial of PCSK9 Inhibitor and Statin Treatment for Carotid Artery Stenosis
A Randomized Clinical TRial on Inhibitor of PCSK9 and Statin Treatment for Carotid Artery Stenosis (TRIP-CAS)
- Status
- Not Yet Recruiting
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 406 (estimated)
- Sponsor
- Changhai Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
A prospective, multicenter, randomized controlled, open-label, blinded outcome evaluation (PROBE) trial.
Detailed description
The trial is to evaluate the effect of ultra-intensive lipid-lowering therapy (PCSK9 inhibitor + rosuvastatin or atorvastatin, with/without ezetimibe) versus conventional lipid-lowering therapy (rosuvastatin or atorvastatin, with/without ezetimibe) on changes in atherosclerotic burden in patients with carotid artery stenosis.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Evolocumab (biweekly injections) + Rosuvastatin/Atorvastatin ± Ezetimibe | PCSK9 inhibitor (biweekly injections) + rosuvastatin/atorvastatin ± ezetimibe |
| DRUG | Rosuvastatin/Atorvastatin ± Ezetimibe | Rosuvastatin/atorvastatin ± ezetimibe |
Timeline
- Start date
- 2025-07-30
- Primary completion
- 2026-06-01
- Completion
- 2027-03-01
- First posted
- 2025-06-25
- Last updated
- 2025-06-25
Source: ClinicalTrials.gov record NCT07036991. Inclusion in this directory is not an endorsement.