NCT07026344

Efficacy of Rescue Stenting/Angioplasty After Failed Thrombectomy for Acute Large Intracranial Vascular Occlusion

Efficacy of Rescue Stenting/Angioplasty After Failed Thrombectomy for Acute Large Intracranial Vascular Occlusion: A Multicenter, Prospective, Open-label, Endpoint-blinded, Randomized Controlled Trial

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 312 (estimated)
• Sponsor: Beijing Anzhen Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The primary objective of this study is to evaluate whether rescue stenting therapy can improve neurological functional outcomes after failed endovascular treatment for acute ischemic stroke caused by large vessel occlusion. The study population is divided into two groups: Stent Placement Group: If recanalization is not achieved after 3-5 attempts of thrombectomy, direct stent placement or balloon angioplasty is performed. Continued Thrombectomy Group: If recanalization is not achieved after 3-5 attempts of thrombectomy, at least one additional thrombectomy attempt is performed. The primary efficacy endpoint is the proportion of patients achieving a modified Rankin Scale (mRS) score of 0-2 at 90±7 days. The safety endpoint is the incidence of symptomatic intracranial hemorrhage within 48 hours after randomization.

Conditions

• Acute Ischemic Stroke

Interventions

Type	Name	Description
PROCEDURE	Stent placement	For patients who fail thrombectomy, perform stent placement.
PROCEDURE	Continued Thrombectomy	For patients with failed thrombectomy, perform at least one additional thrombectomy attempt
PROCEDURE	balloon angioplasty	For patients who fail thrombectomy, perform balloon angioplasty.

Timeline

• Start date: 2025-07-12
• Primary completion: 2027-03-01
• Completion: 2027-04-01
• First posted: 2025-06-18
• Last updated: 2025-08-13

Locations

1 site across 1 country: China