NCT07012590

Morphine and Dexmedetomidine as Adjuvants to Bupivacaine in Ultrasound-guided Erector Spinae Plane Block for Open Subcostal Renal Surgeries

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 147 (actual)
• Sponsor: Kafrelsheikh University · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study aimed to compare the analgesic efficacy between morphine and dexmedetomidine as adjuvants to bupivacaine in ultrasound-guided erector spinae plane block for open subcostal renal surgeries.

Detailed description

The postoperative pain that occurs because of the wide flank incision ranges from a moderate to severe intensity and, in some patients, can become chronic. The erector spinae plane block (ESPB) is a novel interfascial plane technique, aiming to block the dorsal and ventral rami of the spinal nerves to provide visceral and somatic multi-dermatomal analgesia of the cervical, thoracic, and lumbar levels. Adjuvants to local anesthetics, such as morphine and dexmedetomidine, can be used to improve the quality and duration of peripheral nerve block effects.

Conditions

• Morphine
• Dexmedetomidine
• Adjuvants
• Bupivacaine
• Ultrasound
• Erector Spinae Plane Block
• Open Subcostal Renal Surgeries

Interventions

Type	Name	Description
DRUG	Morphine	Patients received erector spinae plane block with morphine 2 mg as an adjuvant to bupivacaine 30 ml 0.25%.
DRUG	Dexmedetomidine	Patients received erector spinae plane block with dexmedetomidine 100 µg as an adjuvant to bupivacaine 30 ml 0.25%.
OTHER	Erector spinae plane block	Patients received erector spinae plane block with bupivacaine 30 ml 0.25% only.

Timeline

• Start date: 2023-05-01
• Primary completion: 2024-07-31
• Completion: 2024-07-31
• First posted: 2025-06-10
• Last updated: 2025-06-10

Locations

1 site across 1 country: Egypt