NCT07010250

Epithelial Dysmetabolism and Renal Fibrosis in ANCA Vasculitis

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 146 (estimated)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The project is to explore in humans the hypothesis of the link between the alteration of tubulo-interstitial metabolism and the rate of deterioration of renal function by comparing various nephropathies.

Detailed description

Patients with ANCA vasculitis with rapidly progressive glomerulonephritis with "crescent" will be compared to six other groups made up of patients with another nephropathy 1/extramembranous glomerulonephritis and 2/ nephropathy with minimal glomerular lesion (LGM) characterized by the absence of significant tubulointerstitial fibrosis lesions and slow evolution towards end-stage chronic renal failure ). Other groups of patients will 3/have interstitial nephropathy, 4/IgA mesangial glomerulopathy , 5/diabetic nephropathy, or 6/collapsing focal segmental hyalinosis.

Conditions

• ANCA Associated Vasculitis
• Extramembranous Glomerulopathy
• Nephrotic Syndrome, Minimal Change
• Interstitial Nephritis
• IgA Nephropathy
• Segmental Hyalinosis
• Diabetic Nephropathies

Timeline

• Start date: 2025-06-02
• Primary completion: 2029-06-02
• Completion: 2029-06-02
• First posted: 2025-06-08
• Last updated: 2025-06-08

Locations

1 site across 1 country: France