NCT07005947

Long COVID-19 Cutaneous Signatures: An ARPA Funded Research Project

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: CND Life Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This is a prospective, longitudinal study involving 300 participants for a single visit to compare Long COVID-19 neurocutaneous biosignatures with those of other disorders affecting the sensory and autonomic nervous system.

Detailed description

This is a prospective, longitudinal study involving 300 participants for a single visit to compare Long COVID-19 neurocutaneous biosignatures with those of other disorders affecting the sensory and autonomic nervous system. The evaluations will include clinical assessments, neurologic exams, patient reported outcome surveys, and skin biopsies from three locations. Data will be collected on the amount of P-SYN in cutaneous nerve fibers. The cohorts of interest are as follows: 1. 100 participants with Long COVID-19 defined by NIH PASC criteria 2. 100 participants with acute COVID-19 who tested positive for COVID-19 without persistent symptoms defined WHO criteria 3. 50 participants with postural orthostatic tachycardia syndrome (POTS) 4. 50 participants with diabetic neuropathy There are no plans for additional visits at this time. If interested to learn more about this study, please complete the form here for someone to contact you. "here" would take you to the said form.

Conditions

• Long COVID-19
• Acute COVID-19
• Postural Orthostatic Tachycardia Syndrome (POTS)
• Diabetic Neuropathy

Timeline

• Start date: 2023-11-30
• Primary completion: 2026-02-28
• Completion: 2026-04-16
• First posted: 2025-06-05
• Last updated: 2026-02-19

Locations

1 site across 1 country: United States