NCT06992544

Trial of Pistachio Consumption in Older Adults

Trial of Pistachio Consumption on Cognition, Cardiometabolic Risk Factors, and Life Satisfaction in Older Adults

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 97 (actual)
• Sponsor: Brigham and Women's Hospital · Academic / Other
• Sex: All
• Age: 65 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The goal of this study is to evaluate whether a pistachio-enriched diet leads to changes in cognitive function, cardiometabolic risk factors, and life satisfaction in older adults over a 6-month period.

Detailed description

In this remote-based, parallel-arm RCT, the investigators will recruit participants from the recently completed COcoa Supplement and Multivitamin Outcomes Study (COSMOS) trial cohort. Eligible COSMOS participants will be invited to participate in the proposed RCT, screened to verify eligibility and willingness to participate, and asked to provide informed consent. Eligible and willing participants will be enrolled and randomized on a rolling basis. Risk factors and Outcome assessments will be conducted at baseline, 3 months and 6 months via the MyCap Mobile Toolbox application, REDCap questionnaires (for life satisfaction, dietary, and other phenotypic assessments), or at a local Quest Diagnostics (for biospecimen collection and return to our biorepository).

Conditions

• Cognition
• Cardiometabolic Risk Factors
• Life Satisfaction

Interventions

Type	Name	Description
OTHER	Pistachio-enriched diet	1 packet/day of approximately 1.25 oz (35 g) of dry roasted, unsalted, shelled pistachio kernels
OTHER	Usual diet	Usual diet (while abstaining from pistachio consumption and limiting other nut consumption to ≤1 serving/week)

Timeline

• Start date: 2025-05-28
• Primary completion: 2026-03-01
• Completion: 2026-06-01
• First posted: 2025-05-28
• Last updated: 2025-09-23

Locations

1 site across 1 country: United States