Trials / Recruiting
RecruitingNCT06984510
Accelerated Biological Aging is Associated With Increased Risk of T2DM in the MASLD Population
Accelerated Biological Aging is Associated With Increased Risk of T2DM in the MASLD Population: a Cohort Study
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 2,720 (estimated)
- Sponsor
- Ningbo No. 1 Hospital · Academic / Other
- Sex
- All
- Age
- 20 Years – 90 Years
- Healthy volunteers
- —
Summary
The association between biological aging and type 2 diabetes mellitus (T2DM) incidence in individuals with and without metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear.We assessed biological age by calculating phenotypic age (PhenoAge), Klemera-Doubal method (KDMAge), and homeostatic dysregulation (HDAge). To examine the association of biological ageing with the risk of T2DM, cox regression models were conducted. Furthermore, we applied survival analysis, restricted cubic spline models and population attributable fraction (PAF) to further evaluate the association between biological ageing and T2DM incidence.
Conditions
- Type 2 Diabetes Mellitus (T2DM)
- Metabolic Dysfunction-Associated Steatotic Liver Disease
- Biological Age
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Observational | Observational |
Timeline
- Start date
- 2025-04-01
- Primary completion
- 2025-12-31
- Completion
- 2025-12-31
- First posted
- 2025-05-22
- Last updated
- 2025-06-04
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT06984510. Inclusion in this directory is not an endorsement.