NCT06981767

Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen Planus

Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen Planus : A Randomized Clinical Trial

• Status: Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 42 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Bromelain, an enzyme extract derived from pineapples, has shown promise due to its anti-inflammatory and wound-healing properties. However, its efficacy in treating oral mucosal ulcers remains unexplored. This study aims to provide clinical evidence on the efficacy of bromelain for managing OLP, potentially offering a safer and more effective treatment option.

Conditions

• Oral Lichen Planus

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Topical Bromelain	A natural enzyme-based formulation derived from pineapple, bromelain in orabase is being investigated for its anti-inflammatory and wound-healing properties. As a non-steroidal alternative, it offers a potentially safer treatment option with minimal side effects.
DRUG	0.1% topical triamcinolone acetonide	A corticosteroid-based standard treatment for OLP, triamcinolone acetonide in orabase is used for its strong anti-inflammatory and immunosuppressive effects. It serves as the conventional treatment versus novel therapy in this study
COMBINATION_PRODUCT	Combination of Topical Bromelain and Triamcinolone Acetonide in Orabase	This novel formulation combines the enzymatic, healing properties of bromelain with the anti-inflammatory property of triamcinolone. It is designed to provide enhanced therapeutic effects through synergistic action, potentially reducing the required corticosteroid dose while improving clinical outcomes.

Timeline

• Start date: 2026-02-18
• Primary completion: 2026-05-15
• Completion: 2026-06-15
• First posted: 2025-05-21
• Last updated: 2026-03-03

Locations

1 site across 1 country: Egypt