Trials / Recruiting
RecruitingNCT06979999
The Effects of Positive End-expiratory Pressure (PEEP) on Optic Nerve Sheath Diameter in Laparoscopic Cholecystectomy
The Effects of Positive End-Expiratory Pressure (PEEP) on Optic Nerve Sheath Diameter (ONSD) in Patients Undergoing Laparoscopic Cholecystectomy Under General Anesthesia: A Prospective Interventional Study
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- Sponsor
- Nigde Omer Halisdemir University · Academic / Other
- Sex
- All
- Age
- 18 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
This prospective interventional study will evaluate the effects of applying positive end-expiratory pressure (PEEP) at 10 cmH₂O on optic nerve sheath diameter (ONSD) in patients undergoing elective laparoscopic cholecystectomy under general anesthesia. A total of approximately 80 adult patients (ASA physical status I-III) will be included following informed consent. ONSD will be measured using a high-frequency linear ultrasound probe at three predefined intraoperative time points: (T0) 10 minutes after initiation of mechanical ventilation, (T1) 10 minutes after pneumoperitoneum creation, and (T2) 30 minutes after pneumoperitoneum creation. Dynamic lung compliance, peak airway pressure (Ppeak), end-tidal CO₂ (EtCO₂), heart rate, mean arterial pressure, and SpO₂ will also be recorded. The aim is to assess whether the application of PEEP influences intracranial pressure indicators, particularly ONSD, during laparoscopic procedures. The study may provide valuable insights into the neurophysiological effects of intra-abdominal pressure and mechanical ventilation strategies in surgical patients.
Conditions
- Positive End-expiratory Pressure (PEEP)
- Intracranial Pressure
- Optic Nerve Sheath Diameter
- Mechanical Ventilation
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Positive End-Expiratory Pressure (PEEP) | Application of 10 cmH₂O PEEP during mechanical ventilation after pneumoperitoneum creation in patients undergoing laparoscopic cholecystectomy. |
Timeline
- Start date
- 2024-04-29
- Primary completion
- 2025-05-29
- Completion
- 2025-07-29
- First posted
- 2025-05-20
- Last updated
- 2025-05-20
Locations
1 site across 1 country: Turkey (Türkiye)
Source: ClinicalTrials.gov record NCT06979999. Inclusion in this directory is not an endorsement.