NCT06974305

PET/MRI/EEG Imaging Study in Epilepsy

Investigation of Interictal Metabolic and Electrophysiologic Changes in Epilepsy Through Trimodal Neuroimaging

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography \[FDG-PET\], and blood flow, measured by functional magnetic resonance imaging \[fMRI\]) relate to abnormal interictal electrical activity associated with epilepsy (measured by electroencephalography \[EEG\]). The study will also compare how the three imaging modalities localize regions of abnormal function in the brain.

Conditions

• Epilepsy

Interventions

Type	Name	Description
RADIATION	FDG-PET/fMRI/EEG imaging	Subject will undergo simultaneous EEG, fMRI, and FDG-PET imaging. This includes the use of a standard injected radioactive marker used in PET imaging.

Timeline

• Start date: 2023-09-21
• Primary completion: 2025-11-30
• Completion: 2025-11-30
• First posted: 2025-05-15
• Last updated: 2025-05-15

Locations

1 site across 1 country: United States