NCT06960967

Effects of Chestnuts on Postprandial Glycaemic Response

Postprandial Effects of Chestnuts on Glycaemic Response: a Cross-over Trial in Healthy Adults

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: Monash University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Nut consumption is known to improve health outcomes, such as reducing the risk of chronic diseases like diabetes, cognitive impairment, and cardiovascular diseases. While most research has focused on walnuts and almonds, there is limited information on the health benefits of chestnuts. Chestnuts are unique among tree nuts due to their high starch and fibre content, along with vitamins E and C, minerals (potassium, phosphorus, magnesium), and polyphenols. Evidence from in vitro and animal studies suggests that chestnuts may positively affect health by regulating the gut microbiome, lowering the glycaemic index, and providing antioxidant benefits. The food industry is also exploring new uses for chestnuts, particularly in gluten-free products, due to their nutritional benefits and good taste. Nonetheless, no research has investigated the health effects of chestnuts in humans. By addressing this gap in the literature, the study may lead to the development of new dietary strategies for improved health outcomes.

Conditions

• Postprandial Glycemia
• Insulin Resistance

Interventions

Type	Name	Description
OTHER	Chestnut meal	Participants will receive an isocaloric baked meal with chestnut flour.
OTHER	Control meal	Participants will receive an isocaloric baked meal without chestnut flour.

Timeline

• Start date: 2025-06-06
• Primary completion: 2025-08-18
• Completion: 2026-04-30
• First posted: 2025-05-07
• Last updated: 2026-03-10

Locations

1 site across 1 country: Australia